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KMID : 0043320060290121114
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Archives of Pharmacal Research
2006 Volume.29 No. 12 p.1114 ~ p.1118
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Effects of (+)-Eudesmin from the Stem Bark of Magnolia kobus DC. var. borealis Sarg. on Neurite Outgrowth in PC12 Cells
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Yang Yoo-Jung
Park Jae-In
Lee Hak-Ju
Seo Seon-Mi
Lee Oh-Kyu
Choi Don-Ha
Paik Ki-Hyon
Lee Myung-Koo
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Abstract
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(+)-Eudesmin [4,8-bis(3,4-dimethoxyphenyl)-3,7 -dioxabicyclo[3.3.0]octane] was isolated from the stem bark of Magnolia kobus DC. var. borealis Sarg. and found to have neuritogenic activity. (+)-eudesmin induced neurite outgrowth and enhanced nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. At this concentration, (+)-eudesmin also enhanced NGF-induced neurite-bearing activity and this activity was partially blocked by various protein kinase inhibitors. These included PD98059, a mitogen-activated protein kinase (MAPK) kinase inhibitor. GF109203X, a protein kinase C (PKC) inhibitor and H89, a protein kinase A (PKA) inhibitor. These results suggest that (+)-eudesmin can induce neurite outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways.
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KEYWORD
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(+)-Eudesmin, Magnolia kobus, Neurite outgrowth, PC12 cells
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